Clinical Studies
Extensive human and animal studies have shown the osteoconductive properties of SynthoGraft:
- Rapid bone regeneration in critical size defects at early implantation times has been observed.
- Micro-computed tomographic analysis of retrieved human cores at 3, 6, and 12 months following sinus lift procedures have shown bone-to-grafting material volume ratios ranging from 78 to 98% as early as 3 months.
- No foreign body responses were detected.
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| A transmission electron micrograph (TEM) showing the structurally interconnected nanometer size porosity of SynthoGraft. | Histologic 3D core reconstruction analysis showed significant new bone formation in sinus grafted regions. |
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| 3 month histology. | 6 month histology. |
| Retrieval of sinus elevations after 3 and 6 months showed progressive resorbtion of SynthoGraft particles and increasing bone regeneration. | |
Laboratory Studies
Extensive laboratory studies have demonstrated the unique physical properties of SynthoGraft:
- Nanometer-scale porosity
- Pure, synthetic material
- Cellular-level biocompatibility
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| Micrometer and nanometer pore size for optimized material dissolution and bone regeneration rates. | In vitro cytotoxicity assays confirmed the cellular-level biocompatibility of SynthoGraft. |
